Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species.

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Article

Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species.

The Journal of biological chemistry - 15 Jul 1993

Margulies L, Sehgal P B

Abstract excerpt

Constitutive up-regulation of interleukin-6 (IL-6) gene expression is observed in many neoplastic cell lines. The contribution of mutations in p53 to the up-regulation of the IL-6 promoter was evaluated in transient transfection experiments. In HeLa cells, wild-type (wt) human or murine p53 prefe...

Topics

Animals
CCAAT-Enhancer-Binding Proteins
DNA-Binding Proteins
Gene Expression Regulation
Genes, p53
HeLa Cells
Humans
Interleukin-6
Mice
Mutation
Nuclear Proteins
Promoter Regions, Genetic
Transcription Factors
Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 8325885

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8325885-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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