Article
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.
Molecular and cellular biology - 1 Jun 1997
Weissinger E M, Eissner G, Grammer C, Fackler S, Haefner B, Yoon L S, Lu K S, Bazarov A, Sedivy J M, Mischak H, Kolch W
Abstract excerpt
Here we investigate the role of the Raf-1 kinase in transformation by the v-abl oncogene. Raf-1 can activate a transforming signalling cascade comprising the consecutive activation of Mek and extracellular-signal-regulated kinases (Erks). In v-abl-transformed cells the endogenous Raf-1 protein wa...
Topics
- 3T3 Cells
- Alleles
- Animals
- Apoptosis
- Blotting, Western
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Transformation, Viral
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Enzyme Activation
- Mice
- Models, Biological
- Oncogene Proteins v-abl
- Oncogene Proteins v-raf