Article
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.
Molecular and cellular biology - 1 Jun 1997
Weissinger E M, Eissner G, Grammer C, Fackler S, Haefner B, Yoon L S, Lu K S, Bazarov A, Sedivy J M, Mischak H, Kolch W
Abstract excerpt
Here we investigate the role of the Raf-1 kinase in transformation by the v-abl oncogene. Raf-1 can activate a transforming signalling cascade comprising the consecutive activation of Mek and extracellular-signal-regulated kinases (Erks). In v-abl-transformed cells the endogenous Raf-1 protein was phosphorylated on tyrosine and displayed high constitutive kinase activity. The activities of the Erks were...
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