Article
MEK kinase activity is not necessary for Raf-1 function.
The EMBO journal - 17 Apr 2001
Hüser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, Sun X M, Brown J, Marais R, Pritchard C
Abstract excerpt
Raf-1 protein kinase has been identified as an integral component of the Ras/Raf/MEK/ERK signalling pathway in mammals. Activation of Raf-1 is achieved by RAS:GTP binding and other events at the plasma membrane including tyrosine phosphorylation at residues 340/341. We have used gene targeting to...
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