Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation.

The Journal of biological chemistry - 28 Mar 2003

Petrenko Oleksi, Fingerle-Rowson Gunter, Peng Tina, Mitchell Robert A, Metz Christine N

Abstract excerpt

Macrophage migration inhibitory factor (MIF) has been shown to functionally inactivate the p53 tumor suppressor and to inhibit p53-responsive gene expression and apoptosis. To better understand the role of MIF in cell growth and tumor biology, we evaluated MIF-null embryonic fibroblasts with respect to their immortalization and transformation properties. Although minor deviations in the growth characteristics of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to E2F Transcription Factors

Share to Macrophage Migration-Inhibitory Factors

Share to Mice, Knockout

Share to Oncogenes

Share to ras Proteins

Source

Identifiers

PMID: 12538581
DOI: 10.1074/jbc.M211985200

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation.PMID 12538581Read ↗

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.Semantic proximity Read ↗

Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor.Semantic proximity Read ↗

ELF4/MEF Activates MDM2 Expression and Blocks Oncogene-Induced p16 Activation To Promote TransformationSemantic proximity Read ↗

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.Semantic proximity Read ↗

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.Semantic proximity Read ↗

Multiple E2F-Induced MicroRNAs Prevent Replicative Stress in Response to Mitogenic SignalingSemantic proximity Read ↗

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.Semantic proximity Read ↗

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.Semantic proximity Read ↗

Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1.Semantic proximity Read ↗

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.Semantic proximity Read ↗

RASless MEFs as a Tool to Study RAS-Dependent and RAS-Independent Functions.Semantic proximity Read ↗

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.