Article
Independently arising macrophage mutants dissociate growth factor-regulated survival and proliferation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1991
Pollard J W, Morgan C J, Dello Sbarba P, Cheers C, Stanley E R
Abstract excerpt
Analysis of a simian virus 40-immortalized colony-stimulating factor 1 (CSF-1) -dependent macrophage cell line (BAC1.2F5) and independently arising autonomous mutants derived from it (aut4A, aut4A.1, aut2A, and aut2A.1) revealed distinct phenotypes. The parental line, BAC1.2F5, is dependent on CSF-1 for survival and growth. Of the mutants derived from BAC1.2F5, aut4A has lost the requirement of CSF-1 for...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Survival
- Kinetics
- Macrophage Colony-Stimulating Factor
- Macrophages
- Mice
- Mutation