Article
The ras and protein kinase A pathways are mutually antagonistic in regulating rat prolactin promoter activity.
Oncogene - 1 Jul 1992
Conrad K E, Gutierrez-Hartmann A
Abstract excerpt
In an attempt to characterize the ras signaling pathway, we studied the effects of expression vectors encoding the valine 12 mutant ras oncogene on rat prolactin (rPRL) promoter activity. Using this approach we have been able to dissect the interplay between the ras and the protein kinase A (PKA) pathways as they relate to neuroendocrine gene activation. Here we show that the ras oncogene product induces rPRL...
Topics
- Animals
- Cell Membrane
- Cell Nucleus
- Colforsin
- Gene Expression Regulation
- Mutation
- Oncogene Protein p21(ras)
- Pituitary Gland
- Prolactin
- Promoter Regions, Genetic
- Protein Kinase Inhibitors