Article
Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting.
Mechanisms of development - 1 Mar 2001
Weber M, Milligan L, Delalbre A, Antoine E, Brunel C, Cathala G, Forné T
Abstract excerpt
The imprinted Igf2 gene is active only on the paternal allele in most tissues. Its imprinting involves a cis-acting imprinting-control region (ICR) located upstream of the neighboring and maternally expressed H19 gene. It is thought that differential methylation of the parental alleles at the ICR is crucial for parental imprinting of both genes. Differentially methylated regions (DMRs) have also been identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.