Article
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Moore T, Constancia M, Zubair M, Bailleul B, Feil R, Sasaki H, Reik W
Abstract excerpt
The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this locus is regulated by parental imprinting. However, despite the existence of putative imprinting control elements in the Igf2 upstream region, imprinted transcriptional repression is abolished by null mutations at the linked H19 locus. To clarify the...
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