Article
The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.
The EMBO journal - 1 Sept 1993
Brandeis M, Kafri T, Ariel M, Chaillet J R, McCarrey J, Razin A, Cedar H
Abstract excerpt
We have investigated the DNA methylation patterns in genomically imprinted genes of the mouse. Both Igf2 and H19 are associated with clear-cut regions of allele-specific paternal modification in late embryonic and adult tissues. By using a sensitive PCR assay, it was possible to follow the methyl...
Topics
- Alleles
- Animals
- Base Sequence
- Blastocyst
- DNA
- DNA Primers
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Dinucleoside Phosphates
- Embryonic and Fetal Development
- Female
- Fertilization
- Genes, Regulator
- Liver
- Male
- Methylation
- Mice
- Mice, Transgenic