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Article

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

The EMBO journal - 1 Sept 1993

Brandeis M, Kafri T, Ariel M, Chaillet J R, McCarrey J, Razin A, Cedar H

Abstract excerpt

We have investigated the DNA methylation patterns in genomically imprinted genes of the mouse. Both Igf2 and H19 are associated with clear-cut regions of allele-specific paternal modification in late embryonic and adult tissues. By using a sensitive PCR assay, it was possible to follow the methylation state of individual HpaII sites in these genes through gametogenesis and embryogenesis. Most of these CpG...

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Identifiers

PMID: 7504628
DOI: 10.1002/j.1460-2075.1993.tb06041.x
PMCID: PMC413643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.PMID 7504628Read ↗

Role for DNA methylation in genomic imprinting.Semantic proximity Read ↗

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes.Semantic proximity Read ↗

Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting.Semantic proximity Read ↗

The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.Semantic proximity Read ↗

Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms.Semantic proximity Read ↗

Coordinated allele-specific histone acetylation at the differentially methylated regions of imprinted genes.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Genomic imprinting in the rat: linkage of Igf2 and H19 genes and opposite parental allele-specific expression during embryogenesis.Semantic proximity Read ↗

Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.Semantic proximity Read ↗

Stage-specific and cell type-specific aspects of genomic imprinting effects in mammals.Semantic proximity Read ↗

Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.Semantic proximity Read ↗

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.Semantic proximity Read ↗

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