Article
Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Forné T, Oswald J, Dean W, Saam J R, Bailleul B, Dandolo L, Tilghman S M, Walter J, Reik W
Abstract excerpt
Recent investigations have shown that the maintenance of genomic imprinting of the murine insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-)-methyltransferase activity, which is required to preserve the paternal specific expression of Igf2, and the H19 gene (lying 90 kb downstream of Igf2 gene), which upon inactivation leads to relaxation of the Igf2 imprint. It is not...
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