Article
Influence of type III collagen genotype on aortic diameter and disease.
The British journal of surgery - 1 Oct 1993
Powell J T, Adamson J, MacSweeney S T, Greenhalgh R M, Humphries S E, Henney A M
Abstract excerpt
Type III collagen contributes to the tensile strength of the aortic wall, and mutations in the type III collagen gene have been suggested as the basis for the familial tendency to abdominal aortic aneurysm (AAA). Variation in this gene was investigated in 153 patients with AAA, 87 with aortoiliac stenosis and 98 age-matched controls. The rare mutation at amino acid 619 of Gly-->Arg, previously associated with AAA...
Topics
- Aged
- Alleles
- Aorta, Abdominal
- Aortic Aneurysm, Abdominal
- Collagen
- Female
- Genotype
- Homozygote
- Humans
- Male
- Pressure
- Tensile Strength