Article
eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm.
Journal of vascular surgery - 1 Sept 2005
Fatini Cinzia, Sofi Francesco, Sticchi Elena, Bolli Paola, Sestini Ilaria, Falciani Michela, Azas Leonidas, Pratesi Giovanni
Abstract excerpt
OBJECTIVE: Abdominal aortic aneurysm (AAA) represents a chronic degenerative condition associated with atherosclerosis. Actually, data from experimental and clinical studies suggest that nitric oxide (NO) is a modulator in maintaining endothelial function and antithrombotic intravascular environment. Reduced vascular NO generation in subjects carrying the rare variants of the eNOS gene might predispose to AAA. No...
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