Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts.

doi:10.1161/ATVBAHA.107.155564

Article

Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2008

Jones Gregory T, Thompson Andrew R, van Bockxmeer Frank M, Hafez Hany, Cooper Jackie A, Golledge Jonathan, Humphries Stephen E, Norman Paul E, van Rij Andre M

Abstract excerpt

OBJECTIVE: Although polymorphic variations in genes of the RAS system have previously been associated with susceptibility to AAA, such studies have been significantly limited by small sample sizes. This study was undertaken, using the largest case series yet reported, to determine whether common genetic variants of the RAS are associated with either susceptibility or severity of AAA. METHODS AND RESULTS: The...

Topics

Aged
Aged, 80 and over
Alleles
Amino Acid Substitution
Angiotensinogen
Aortic Aneurysm, Abdominal
Australia
Base Sequence
Cohort Studies
Female

Gene Frequency

Genotype

Humans

Male

Middle Aged

Mutagenesis, Insertional

New Zealand

Peptidyl-Dipeptidase A

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