Article
Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms.
The Journal of clinical investigation - 1 Jun 1993
Tromp G, Wu Y, Prockop D J, Madhatheri S L, Kleinert C, Earley J J, Zhuang J, Norrgård O, Darling R C, Abbott W M
Abstract excerpt
Detailed DNA sequencing of the triple-helical domain of type III procollagen was carried out on cDNA prepared from 54 patients with aortic aneurysms. The 43 male and 11 female patients originated from 50 different families and five different nationalities. 43 patients had at least one additional...
Topics
- Adult
- Aged
- Aneurysm
- Base Sequence
- Canada
- Causality
- Coronary Aneurysm
- Female
- Finland
- Genetic Variation
- Haiti
- Heterozygote
- Humans
- Male
- Middle Aged