Chemoresistant cell lines: morphonuclear characteristics and chemosensitivity development during long-term culture.

Abstract excerpt

The aims of the present work were first to study the stability of the sensitivity and resistance of various cancer cell lines over the period of one year, and second to attempt to correlate the morphological aspects of the lines with the results obtained. To this end we used one mammary and two human vesical lines, each consisting of three different phenotypes: a primitive phenotype (the sensitive line); a...

Topics

• Adenocarcinoma
• Animals
• Chromatin
• Doxorubicin
• Drug Resistance
• Humans
• Image Processing, Computer-Assisted
• Mice
• Phenotype
• Tumor Cells, Cultured
• Urinary Bladder Neoplasms
• Vinblastine