Article
Cytokeratin expression results in a drug-resistant phenotype to six different chemotherapeutic agents.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 1996
Anderson J M, Heindl L M, Bauman P A, Ludi C W, Dalton W S, Cress A E
Abstract excerpt
The cytokeratin network is an abundant cytoplasmic system whose function is largely unknown. Recently, we have found that the introduction of a cytokeratin network into eukaryotic cells results in a drug resistance phenotype. The current study was undertaken to determine the universal nature of t...
Topics
- 3T3 Cells
- Animals
- Antineoplastic Agents
- Apoptosis
- DNA
- DNA Damage
- DNA Fragmentation
- Drug Resistance, Neoplasm
- Keratins
- Mice
- Phenotype