Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytokeratin expression results in a drug-resistant phenotype to six different chemotherapeutic agents.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 1996

Anderson J M, Heindl L M, Bauman P A, Ludi C W, Dalton W S, Cress A E

Abstract excerpt

The cytokeratin network is an abundant cytoplasmic system whose function is largely unknown. Recently, we have found that the introduction of a cytokeratin network into eukaryotic cells results in a drug resistance phenotype. The current study was undertaken to determine the universal nature of this phenomenon by investigating the survival response of two different cell lines to six different DNA-damaging agents...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apoptosis

Share to DNA Damage

Share to Keratins

Share to Phenotype

Source

Identifiers

PMID: 9816096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytokeratin expression results in a drug-resistant phenotype to six different chemotherapeutic agents.PMID 9816096Read ↗

Resistance to Bleomycin in Cancer Cell Lines Is Characterized by Prolonged Doubling Time, Reduced DNA Damage and Evasion of G2/M Arrest and ApoptosisSemantic proximity Read ↗

Selection for Drug Resistance Results in Resistance to Fas-Mediated ApoptosisSemantic proximity Read ↗

Mitomycin–DNA Adducts Induce p53-Dependent and p53-Independent Cell Death PathwaysSemantic proximity Read ↗

Pleiotropic drug resistance and survival advantage in leukemic cells with diminished apoptotic response.Semantic proximity Read ↗

A Chemosensitization Screen Identifies TP53RK, a Kinase that Restrains Apoptosis after Mitotic StressSemantic proximity Read ↗

Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features.Semantic proximity Read ↗

Insights into apoptosis mechanisms induced by DNA-damaging agents in Burkitt's lymphoma cells.Semantic proximity Read ↗

Co-expression of cytokeratin 8 and breast cancer resistant protein indicates a multifactorial drug-resistant phenotype in human breast cancer cell line.Semantic proximity Read ↗

Morphologic alterations in drug sensitive vs. drug resistant cells due to cytostatic application.Semantic proximity Read ↗

Apoptosis Genes and Resistance to Cancer Therapy: What Does the Experimental and Clinical Data Tell Us?Semantic proximity Read ↗

The Possible Role of Cytokeratin 8 in Cadmium-Induced Adaptation and CarcinogenesisSemantic proximity Read ↗

Theranostic proteomic profiling of cyclins, cyclin dependent kinases and Ras in human cancer cell lines is dependent on p53 mutational status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.