Article
Digital morphonuclear analyses of sensitive versus resistant neoplastic cells to vinca-alkaloid, alkylating, and intercalating drugs.
Cytometry - 1 Jan 1991
Pauwels O, Kiss R
Abstract excerpt
We tested 12 resistant cell lines in vitro in order to evaluate common morphonuclear characteristics induced by various cytotoxic drugs on cell lines of different origins. We used the MXT mouse mammary cancer and the neoplastic J82 and T24 human bladder cell lines, whose variants are either sensi...
Topics
- Alkylating Agents
- Animals
- Antineoplastic Agents
- Cell Nucleus
- Cell Transformation, Neoplastic
- DNA, Neoplasm
- Doxorubicin
- Drug Hypersensitivity
- Drug Resistance
- Humans
- Image Processing, Computer-Assisted
- Mammary Neoplasms, Experimental
- Mice
- Multivariate Analysis
- Organic Chemicals
- Phenotype
- Tumor Cells, Cultured
- Urinary Bladder Neoplasms