Article
Heterogeneity and phenotypic instability of chemotherapeutic and immunologic sensitivity in murine and human melanoma cell clones.
Tumori - 29 Feb 1992
Supino R, Rodolfo M, Mariani M, Mapelli E
Abstract excerpt
The aim of the present study was to examine the phenotypic heterogeneity of murine and human melanoma cell lines with particular reference to anticancer drug sensitivity, growth pattern and susceptibility to lysis by lymphokine (rIL2) activated killer (LAK cells). Clones selected for a different...
Topics
- Animals
- Cell Line
- Clone Cells
- Cytotoxicity Tests, Immunologic
- Doxorubicin
- Drug Screening Assays, Antitumor
- Humans
- Interleukin-2
- Killer Cells, Lymphokine-Activated
- Lymphocyte Activation
- Melanoma
- Melanoma, Experimental
- Mice
- Phenotype
- Recombinant Proteins
- Tumor Cells, Cultured