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Article

High-performance liquid chromatography determination of dextromethorphan and dextrorphan for oxidation phenotyping by fluorescence and ultraviolet detection.

Therapeutic drug monitoring - 1 Aug 1993

Lam Y W, Rodriguez S Y

Abstract excerpt

To establish the usefulness of fluorescence detection to quantify urinary concentrations of dextromethorphan and dextrorphan for oxidation phenotyping, we determined the molar concentration ratio of dextromethorphan to dextrorphan in 38 subjects by UV and fluorescence detection. Dextromethorphan and dextrorphan concentrations were quantified after overnight hydrolysis of urine samples and organic solvent...

Topics

Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Dextromethorphan
Dextrorphan
Humans
Mixed Function Oxygenases
Oxidation-Reduction
Phenotype
Spectrometry, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spectrophotometry, Ultraviolet

Source

Identifiers

PMID: 8236365
DOI: 10.1097/00007691-199308000-00007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8236365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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