Article
A rapid thin layer chromatographic procedure to identify poor and extensive oxidative drug metabolizers in man using dextromethorphan.
Die Pharmazie - 1 May 1992
De Zeeuw R A, Eikema D, Franke J P, Jonkman J H
Abstract excerpt
A rapid TLC method is presented to distinguish poor oxidative drug metabolizers from extensive oxidative drug metabolizers. Dextromethorphan (1) is used as test probe because it is safe, well characterized, generally available and easy to measure. The method is based on the extraction of 1 and its major oxidative metabolite dextrorphan (2) from urine, followed by separation on a TLC plate and visualized by a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.