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Article

A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors.

The Journal of clinical investigation - 15 Nov 1998

Winters M A, Coolley K L, Girard Y A, Levee D J, Hamdan H, Shafer R W, Katzenstein D A, Merigan T C

Abstract excerpt

While many point mutations in the HIV-1 reverse transcriptase (RT) confer resistance to antiretroviral drugs, inserts or deletions in this gene have not been previously characterized. In this report, 14 RT inhibitor-treated patients were found to have HIV-1 strains possessing a 6-basepair insert between codons 69 and 70 of the RT gene. Known drug resistance mutations were also observed in these strains, with...

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Identifiers

PMID: 9819361
DOI: 10.1172/JCI4948
PMCID: PMC509125

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Source receipt: pubmed, retrieved 7 Sept 2026.

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