Article
A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors.
The Journal of clinical investigation - 15 Nov 1998
Winters M A, Coolley K L, Girard Y A, Levee D J, Hamdan H, Shafer R W, Katzenstein D A, Merigan T C
Abstract excerpt
While many point mutations in the HIV-1 reverse transcriptase (RT) confer resistance to antiretroviral drugs, inserts or deletions in this gene have not been previously characterized. In this report, 14 RT inhibitor-treated patients were found to have HIV-1 strains possessing a 6-basepair insert...
Topics
- Amino Acid Sequence
- Anti-HIV Agents
- Base Sequence
- Cells, Cultured
- Didanosine
- Drug Resistance, Multiple
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Nucleosides
- Reverse Transcriptase Inhibitors