Article
Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells.
Growth factors (Chur, Switzerland) - 1 Jan 1994
Maliakal J C, Asahina I, Hauschka P V, Sampath T K
Abstract excerpt
We recently showed that osteogenic protein-1(OP-1), a bone morphogenetic protein member of TGF-beta superfamily, induces endochondral bone formation in vivo, and stimulates growth and differentiation of osteoblasts in rat calvarial-derived cell cultures. In the present study, we examined the effe...
Topics
- Alkaline Phosphatase
- Animals
- Biomarkers
- Blotting, Northern
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins
- Cell Differentiation
- Cell Division
- Collagen
- Cyclic AMP
- DNA
- Gene Expression
- Osteoblasts
- Osteocalcin
- Osteosarcoma
- Phenotype
- Proteins
- Rats