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Article

Establishing an immortalized human osteoprecursor cell line: OPC1.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 1999

Winn S R, Randolph G, Uludag H, Wong S C, Hair G A, Hollinger J O

Abstract excerpt

The present studies evaluated the feasibility of establishing a conditionally immortalized osteoprecursor cell line derived from human fetal bone tissue. Primary cultures were transfected with a plasmid in which the Mx-1 promoter drives the expression of SV40 T-antigen when activated by human A/D interferon. Several neomycin (G418)-resistant colonies were characterized for cell growth and alkaline phosphatase...

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Identifiers

PMID: 10491220
DOI: 10.1359/jbmr.1999.14.10.1721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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