Post-translational processing of proopiomelanocortin (POMC) in mouse pituitary melanotroph tumors induced by a POMC-simian virus 40 large T antigen transgene.

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Article

Post-translational processing of proopiomelanocortin (POMC) in mouse pituitary melanotroph tumors induced by a POMC-simian virus 40 large T antigen transgene.

The Journal of biological chemistry - 25 Nov 1993

Low M J, Liu B, Hammer G D, Rubinstein M, Allen R G

Abstract excerpt

Mice harboring a transgene composed of proopiomelanocortin (POMC) gene promoter sequences (nucleotides -706 to +64) ligated to the simian virus (SV) 40 early gene encoding large T antigen developed large POMC-expressing pituitary tumors. Histologically the tumors arose from the intermediate lobe, contained nuclear SV40 T antigen and POMC peptides, but did not express other pituitary hormones. POMC processing in...

Topics

Adrenocorticotropic Hormone
Animals
Antigens, Polyomavirus Transforming
Aspartic Acid Endopeptidases
Mice
Mice, Nude
Mice, Transgenic
Neoplasm Transplantation
Phenotype
Pituitary Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pro-Opiomelanocortin

Proprotein Convertase 1

Proprotein Convertase 2

Proprotein Convertases

Protein Processing, Post-Translational

RNA, Messenger

Subtilisins

beta-Endorphin

Source

Open in PubMed

Identifiers

PMID: 8227058

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8227058-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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