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Article

Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture.

The Journal of investigative dermatology - 1 Sept 1998

Can G, Abdel-Malek Z, Porter-Gill P A, Gill P, Boyce S, Grabowski G A, Nordlund J, Farooqui J

Abstract excerpt

Proopiomelanocortin (POMC) is a precursor polypeptide for various bioactive peptides, including adrenocorticotropic hormone, alpha-, beta-, and gamma-melanotropin, beta-endorphin, and beta-lipotropin. Although the classical source of POMC is the pituitary, various studies indicate the expression of POMC in several nonpituitary tissues. In this study, in situ hybridization with anti-sense cRNA riboprobe was used...

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Source

Identifiers

PMID: 9740245
DOI: 10.1046/j.1523-1747.1998.00315.x

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture.PMID 9740245Read ↗

Differential expression of proopiomelanocortin (POMC) transcriptional variants in human skin cells.Semantic proximity Read ↗

Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skinSemantic proximity Read ↗

Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors.Semantic proximity Read ↗

The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skinSemantic proximity Read ↗

Gene expression analysis of the corticotrophin-releasing hormone-proopiomelanocortin system in psoriasis skin biopsies.Semantic proximity Read ↗

A case of early-onset obesity, hypocortisolism, and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin (POMC) gene in an Indian boy.Semantic proximity Read ↗

Implications of proopiomelanocortin (POMC) mutations in humans: the POMC deficiency syndrome.Semantic proximity Read ↗

Mutations in the human proopiomelanocortin gene.Semantic proximity Read ↗

60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease.Semantic proximity Read ↗

Implications of the phenotype of POMC deficiency for the role of POMC-derived peptides in skin physiology.Semantic proximity Read ↗

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.Semantic proximity Read ↗

A Founder Mutation in the POMC 5'-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA.Semantic proximity Read ↗

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