Article
Two distinct pituitary cell lines from mouse intermediate lobe tumors: a cell that produces prolactin-regulating factor and a melanotroph [seecomments].
Endocrinology - 1 Dec 1997
Hnasko R, Khurana S, Shackleford N, Steinmetz R, Low M J, Ben-Jonathan N
Abstract excerpt
The intermediate lobe (IL) of the pituitary produces a PRL-regulating factor (PRF). Targeted tumorigenesis, using the POMC promoter ligated to SV40 large T antigen (Tag), generated transgenic mice that develop IL tumors with PRF activity. Our goal was to establish and characterize a PRF-producing...
Topics
- Animals
- Cell Division
- Chromatography, High Pressure Liquid
- Coculture Techniques
- Female
- Male
- Melanocyte-Stimulating Hormones
- Mice
- Mice, Transgenic
- Phenotype
- Pituitary Gland, Anterior
- Pituitary Neoplasms
- Polymerase Chain Reaction
- Rats
- Rats, Inbred F344