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Article

The HIR4-1 mutation defines a new class of histone regulatory genes in Saccharomyces cerevisiae.

Genetics - 1 Sept 1993

Spector M S, Osley M A

Abstract excerpt

Both activation and repression have been implicated in the cell cycle-regulated transcription of the histone HTA1-HTB1 locus in Saccharomyces cerevisiae. Transcriptional repressors have been identified through the isolation of recessive mutations in the HIR1, HIR2 and HIR3 genes. These three regulatory genes encode proteins that act at a negative site in the HTA1-HTB1 promoter, and their inactivation results in...

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Identifiers

PMID: 8224824
DOI: 10.1093/genetics/135.1.25
PMCID: PMC1205623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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