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Article

Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.

Genetics - 1 Feb 1998

DeSilva H, Lee K, Osley M A

Abstract excerpt

The HIR1 gene product is required to repress transcription of three of the four histone gene loci in Saccharomyces cerivisiae, and like its counterpart, the HIR2 protein, it functions as a transcriptional corepressor. Although Hir1p and Hir2p are physically associated in yeast, Hir1p is able to function independently of Hir2p when it is artificially recruited to the histone HTA1 promoter. A deletion analysis of...

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PMID: 9504914
DOI: 10.1093/genetics/148.2.657
PMCID: PMC1459821

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