Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.

doi:10.1093/genetics/148.2.657

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Article

Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.

Genetics - 1 Feb 1998

DeSilva H, Lee K, Osley M A

Abstract excerpt

The HIR1 gene product is required to repress transcription of three of the four histone gene loci in Saccharomyces cerivisiae, and like its counterpart, the HIR2 protein, it functions as a transcriptional corepressor. Although Hir1p and Hir2p are physically associated in yeast, Hir1p is able to f...

Topics

DNA Mutational Analysis
Fungal Proteins
Gene Expression Regulation, Fungal
Histones
Mutation
Nuclear Proteins
Phenotype
Promoter Regions, Genetic
RNA, Messenger
Repressor Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription, Genetic

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