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Article

HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Mar 1995

Zhu Y, Peterson C L, Christman M F

Abstract excerpt

The Hpr1 protein has an unknown function, although it contains a region of homology to DNA topoisomerase I. We have found that hpr1 null mutants are defective in the transcription of many physiologically unrelated genes, including GAL1, HO, ADH1, and SUC2, by using a combination of Northern (RNA) blot analysis, primer extension, and upstream activation sequence-lacZ fusions. Many of the genes positively regulated...

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Identifiers

PMID: 7862161
DOI: 10.1128/MCB.15.3.1698
PMCID: PMC230394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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