HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae.

doi:10.1128/MCB.15.3.1698

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Article

HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Mar 1995

Zhu Y, Peterson C L, Christman M F

Abstract excerpt

The Hpr1 protein has an unknown function, although it contains a region of homology to DNA topoisomerase I. We have found that hpr1 null mutants are defective in the transcription of many physiologically unrelated genes, including GAL1, HO, ADH1, and SUC2, by using a combination of Northern (RNA) blot analysis, primer extension, and upstream activation sequence-lacZ fusions. Many of the genes positively regulated...

Topics

Base Sequence
Chromatography, Gel
Chromatography, High Pressure Liquid
DNA Primers
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Genotype
Methyltransferases
Molecular Sequence Data
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Polymerase Chain Reaction

Promoter Regions, Genetic

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 7862161
DOI: 10.1128/MCB.15.3.1698
PMCID: PMC230394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7862161-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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