Article
Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription.
Genetics - 1 Jun 2001
Sutton A, Bucaria J, Osley M A, Sternglanz R
Abstract excerpt
Transcription of the four yeast histone gene pairs (HTA1-HTB1, HTA2-HTB2, HHT1-HHF1, and HHT2-HHF2) is repressed during G1, G2, and M. For all except HTA2-HTB2, this repression requires several trans-acting factors, including the products of the HIR genes, HIR1, HIR2, and HIR3. ASF1 is a highly conserved protein that has been implicated in transcriptional silencing and chromatin assembly. In this analysis, we...
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