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Article

Histone regulatory (hir) mutations suppress delta insertion alleles in Saccharomyces cerevisiae.

Genetics - 1 Aug 1991

Sherwood P W, Osley M A

Abstract excerpt

Changes in histone gene dosage as well as mutations within some histone genes suppress delta insertion mutations in the HIS4 and LYS2 loci of Saccharomyces cerevisiae by altering the site of transcription initiation. We have found that three histone regulatory (hir) mutations, identified by their effects on the regulation of histone gene expression, suppress the same insertion mutations. In addition, we have...

Topics

Alleles
Blotting, Northern
DNA Transposable Elements
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Recessive
Genes, Regulator
Histones
Multigene Family
Saccharomyces cerevisiae
Suppression, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 1655565
DOI: 10.1093/genetics/128.4.729
PMCID: PMC1204547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655565-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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