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Article

The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.

Molecular and cellular biology - 1 Sept 2009

Anderson Holly E, Wardle Josephine, Korkut Senay Vural, Murton Heather E, López-Maury Luis, Bähler Jürg, Whitehall Simon K

Abstract excerpt

The assembly of nucleosomes by histone chaperones is an important component of transcriptional regulation. Here, we have assessed the global roles of the HIRA histone chaperone in Schizosaccharomyces pombe. Microarray analysis indicates that inactivation of the HIRA complex results in increased expression of at least 4% of fission yeast genes. HIRA-regulated genes overlap with those which are normally repressed...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19620282
DOI: 10.1128/MCB.00698-09
PMCID: PMC2738286

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.PMID 19620282Read ↗

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