Article
HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant.
FEMS yeast research - 1 Dec 2005
Mazzoni Cristina, Palermo Vanessa, Torella Mirko, Falcone Claudio
Abstract excerpt
We previously have reported that Saccharomyces cerevisiae mutants expressing Kllsm4Delta1, a truncated form of the KlLSM4 gene, as well as mutants in genes of the mRNA-decapping pathway, show phenotypic markers of apoptosis, increased temperature sensitivity and reduced growth in the presence of different drugs and oxidative stressing agents, such as acetic acid and H(2)O(2). To isolate multicopy extra-genic...
Topics
- Acetic Acid
- Amino Acid Sequence
- Antifungal Agents
- Apoptosis
- Cellular Senescence
- DNA Fragmentation
- Drug Resistance, Fungal
- Gene Deletion
- Gene Dosage
- Gene Expression Profiling
- Gene Library
- Genetic Complementation Test
- Histones