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Article

Two mutations affecting conserved residues in the Met receptor operate via different mechanisms.

Oncogene - 2 Mar 2000

Maritano D, Accornero P, Bonifaci N, Ponzetto C

Abstract excerpt

We have investigated the mechanism by which two oncogenic mutations (M1268T and D1246H/N; Amino-acids are numbered according to Schmidt et al., 1999) affecting conserved residues in the catalytic domain of the Met receptor, activate its transforming potential. Both mutations were previously found in tumorigenic forms of the Ret and Kit receptors, respectively. The mutated residues are located either in the P+1...

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Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Pore Complex Proteins

Share to Proto-Oncogene Proteins c-kit

Share to Proto-Oncogene Proteins c-met

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Source

Identifiers

PMID: 10713677
DOI: 10.1038/sj.onc.1203431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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