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Article

Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation.

Blood - 15 Jul 2004

Chen Jing, Williams Ifor R, Kutok Jeffery L, Duclos Nicole, Anastasiadou Ema, Masters Shane C, Fu Haian, Gilliland D Gary

Abstract excerpt

TEL-platelet-derived growth factor-beta receptor (TEL-PDGFbetaR) is expressed in chronic myelomonocytic leukemias associated with t(5;12)(q33;p13), and the fusion tyrosine kinase retains a conserved WW-like domain in the PDGFbetaR autoinhibitory juxtamembrane region. Here we report that mutation...

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Share to Amino Acid Sequence
Share to Cell Transformation, Neoplastic
Share to Leukemia, Myelomonocytic, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

Share to Phosphorylation

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 15054045
DOI: 10.1182/blood-2004-01-0169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15054045-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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