Activation of the JNK pathway is essential for transformation by the Met oncogene.

doi:10.1093/emboj/16.10.2634

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Article

Activation of the JNK pathway is essential for transformation by the Met oncogene.

The EMBO journal - 15 May 1997

Rodrigues G A, Park M, Schlessinger J

Abstract excerpt

The Met/Hepatocyte Growth Factor (HGF) receptor tyrosine kinase is oncogenically activated through a rearrangement that creates a hybrid gene Tpr-Met. The resultant chimeric p65(Tpr-Met) protein is constitutively phosphorylated on tyrosine residues in vivo and associates with a number of SH2-cont...

Topics

Adaptor Proteins, Signal Transducing
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Transformation, Neoplastic
ErbB Receptors
Fibroblasts
GRB2 Adaptor Protein
GTP-Binding Proteins
Membrane Proteins
Mutation
Nuclear Pore Complex Proteins
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)
Protein Binding
Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-met
Rats

Source

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Identifiers

PMID: 9184210
DOI: 10.1093/emboj/16.10.2634
PMCID: PMC1169874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9184210-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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