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Article

Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function.

The Journal of biological chemistry - 6 May 2011

Xu Yiru, Xia Wei, Baker Dustin, Zhou Jin, Cha Hyuk Chol, Voorhees John J, Fisher Gary J

Abstract excerpt

Protein tyrosine phosphorylation is a ubiquitous, fundamental biochemical mechanism that regulates essential eukaryotic cellular functions. The level of tyrosine phosphorylation of specific proteins is finely tuned by the dynamic balance between protein tyrosine kinase and protein tyrosine phosphatase activities. Hepatocyte growth factor receptor (also known as Met), a receptor protein tyrosine kinase, is a major...

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PMID: 21454675
DOI: 10.1074/jbc.M110.212597
PMCID: PMC3091207

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HGF

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