Paternal origin of the rearranged major breakpoint cluster region in chronic myeloid leukemia.

Article

Paternal origin of the rearranged major breakpoint cluster region in chronic myeloid leukemia.

Blood - 15 Jun 1994

Litz C E, Copenhaver C M

Abstract excerpt

The Philadelphia chromosome, t(9;22), is present in virtually all cases of chronic myeloid leukemia (CML). It has previously been shown by cytogenetic studies that the rearranged chromosome 22 in patients with CML is exclusively maternal in origin. To address this issue at a molecular level, the...

Topics

Adult
Alleles
Child, Preschool
Chromosomes, Human, Pair 22
Fathers
Female
Gene Rearrangement
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Male
Oncogene Proteins
Oncogenes
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcr

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