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FISH mapping of Philadelphia negative BCR/ABL1 positive CML

18 Jul 2008

Abstract excerpt

BACKGROUND: Chronic myeloid leukaemia (CML) is a haematopoietic stem cell disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or its variants. The Ph results in the formation of the BCR/ABL1 fusion gene, which is a constitutively activated tyrosine kinase. Around 1% of CML patients appear to have a Ph negative karyotype but carry a cryptic...

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PMID: 18638369
DOI: 10.1186/1755-8166-1-14

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