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Cytogenetic and Molecular Genetic Aspects of Chronic Myeloid Leukaemia

1 Jan 2002

Abstract excerpt

Chronic myeloid leukaemia (CML) is caused by the product of the BCR-ABL oncogene, located on the Philadelphia (Ph) chromosome. BCR-ABL is generated as a result of a reciprocal t(9;22) chromosomal translocation. The mechanisms responsible for this illegitimate recombination event remain elusive but are presumed to require a close spatial association of the translocation partners (chromosomes 9 and 22). BCR-ABL...

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PMID: 12432215
DOI: 10.1159/000065655

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