Article
Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases.
Hematologic pathology - 1 Jan 1992
Karlic H, Grill R, Schlögl E
Abstract excerpt
The chromosome 22 derivative, the Philadelphia (Ph) chromosome, results from the reciprocal translocation t(9;22) (q34;q11). On DNA level a BCR/ABL rearrangement involving the so-called major BCR (Mbcr) from chromosome 22 has been associated with chronic myeloid leukemia (CML). For Ph+ ALL a site of rearrangements in the 5' part of the BCR (breakpoint cluster region) gene on chromosome 22, the so-called minor bcr...
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