Article
Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases.
Hematologic pathology - 1 Jan 1992
Karlic H, Grill R, Schlögl E
Abstract excerpt
The chromosome 22 derivative, the Philadelphia (Ph) chromosome, results from the reciprocal translocation t(9;22) (q34;q11). On DNA level a BCR/ABL rearrangement involving the so-called major BCR (Mbcr) from chromosome 22 has been associated with chronic myeloid leukemia (CML). For Ph+ ALL a site of rearrangements in the 5' part of the BCR (breakpoint cluster region) gene on chromosome 22, the so-called minor bcr...
Topics
- Alleles
- DNA, Neoplasm
- Gene Rearrangement
- Humans
- Incidence
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Reference Values