Article
Aberrant methylation of the major breakpoint cluster region in chronic myeloid leukemia.
Blood - 15 Sept 1996
Litz C E, Vos J A, Copenhaver C M
Abstract excerpt
Isolated hypomethylated sites exist in the major breakpoint cluster region (M-bcr) where most Philadelphia chromosome (Ph) breakpoints are located. Twenty of 50 (40%) chronic myeloid leukemia (CML) patients were found to have aberrant hypermethylation of these sites on the rearranged M-bcr when c...
Topics
- Alleles
- Base Sequence
- Bone Marrow Cells
- Bone Marrow Transplantation
- Chromosome Mapping
- Chromosomes, Human, Pair 22
- DNA Primers
- DNA, Neoplasm
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Methylation
- Molecular Sequence Data
- Oncogene Proteins
- Philadelphia Chromosome
- Polymorphism, Restriction Fragment Length
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcr