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Article

Aberrant methylation of the major breakpoint cluster region in chronic myeloid leukemia.

Blood - 15 Sept 1996

Litz C E, Vos J A, Copenhaver C M

Abstract excerpt

Isolated hypomethylated sites exist in the major breakpoint cluster region (M-bcr) where most Philadelphia chromosome (Ph) breakpoints are located. Twenty of 50 (40%) chronic myeloid leukemia (CML) patients were found to have aberrant hypermethylation of these sites on the rearranged M-bcr when compared with control marrows. The aberrancy correlated strongly with M-bcr breakpoint location; 19 of 20 cases had...

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PMID: 8822945

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