Article
Are ABL and BCR imprinted? No definitive answers, but more questions.
Leukemia - 1 Apr 1995
Haas O A
Abstract excerpt
The apparent nonrandom contribution of the paternally-derived chromosome 9 and the maternally-derived chromosome 22 to the leukemia-specific translocation t(9;22)(q34;q11) obtained by cytogenetic analysis suggested that the two genes affected by this rearrangement, namely ABL and BCR, are imprinted. The results of recent molecular genetic studies have challenged this notion, since it was shown that both the...
Topics
- Alleles
- DNA Replication
- Female
- Fusion Proteins, bcr-abl
- Genes, abl
- Humans
- Imprinting, Psychological
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Methylation
- Philadelphia Chromosome
- Translocation, Genetic