Methylation status of the major breakpoint cluster region in Philadelphia chromosome negative leukemias.

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Article

Methylation status of the major breakpoint cluster region in Philadelphia chromosome negative leukemias.

Leukemia - 1 Jan 1992

Litz C E, McClure J S, Coad J E, Goldfarb A N, Brunning R D

Abstract excerpt

It has been shown that a 600 bp long cluster of cell lineage specific hypomethylated sites in the major breakpoint cluster region (M-bcr) on chromosome 22 exists in hematopoietic cells. To determine possible relationships between methylation patterns within the M-bcr and the stage of hematopoieti...

Topics

Acute Disease
Alleles
Anemia, Refractory
Chromosomes, Human, Pair 22
DNA, Neoplasm
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Myeloid
Lymphoma, Non-Hodgkin
Methylation
Neutrophils
Polymorphism, Restriction Fragment Length
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 1346543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1346543-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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