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Article

Methylation status of the major breakpoint cluster region in Philadelphia chromosome negative leukemias.

Leukemia - 1 Jan 1992

Litz C E, McClure J S, Coad J E, Goldfarb A N, Brunning R D

Abstract excerpt

It has been shown that a 600 bp long cluster of cell lineage specific hypomethylated sites in the major breakpoint cluster region (M-bcr) on chromosome 22 exists in hematopoietic cells. To determine possible relationships between methylation patterns within the M-bcr and the stage of hematopoietic cell development, the M-bcr methylation status of 39 patients with leukemia and lymphoma and two patients with...

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PMID: 1346543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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