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Article

Consistent involvement of the bcr gene by 9;22 breakpoints in pediatric acute leukemias

15 Jan 1991

Abstract excerpt

To investigate the relationship of bcr-abl fusion mRNAs with childhood acute lymphoblastic leukemias (ALL), we examined 27 pediatric Philadelphia chromosome (Ph1)-positive acute leukemias using a reverse polymerase chain reaction (PCR) procedure. In cells from 24 leukemias, single bcr-abl PCR products were detected that corresponded to breakpoints in the minor breakpoint cluster region (mbcr in intron 1 of the...

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Identifiers

PMID: 1985699
DOI: 10.1182/blood.v77.2.324.324

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