Article
Novel Philadelphia variant t(Y;9;22)(q12;q34;q11) in a case of chronic myeloid leukemia.
Cancer genetics and cytogenetics - 15 Oct 1999
Dierlamm J, Michaux L, Stefanova M, Eggert J, Leberecht P, Seeger D, Westerhausen M, Hossfeld D K
Abstract excerpt
A novel Philadelphia (Ph) variant translocation, t(Y;9;22)(q12;q34;q11), was detected in a 63-year-old man with a newly diagnosed chronic myeloid leukemia (CML). Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed a b3a2 fusion transcript. Fluorescence in situ hybridization (FISH) utilizing library probes, subtelomeric cosmid probes, and probes hybridizing to the ABL and BCR genes showed a...
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