Article
Balanced parental contribution to the ABL component of the BCR-ABL gene in chronic myeloid leukemia.
Leukemia - 1 Apr 1995
Melo J V, Yan X H, Diamond J, Goldman J M
Abstract excerpt
Genomic imprinting has recently been associated with the reciprocal t(9;22) chromosome translocation of chronic myeloid leukaemia (CML). This translocation gives rise to a 22q-, or Philadelphia (Ph), chromosome and a derivative 9q+. Based on heterochromatin polymorphisms, it was reported that the...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Female
- Fusion Proteins, bcr-abl
- Gene Expression
- Genomic Imprinting
- Heterozygote
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Molecular Sequence Data
- Parents
- Philadelphia Chromosome
- RNA, Messenger
- RNA, Neoplasm
