Article
Genomic deletions on other chromosomes involved in variant t(9;22) chronic myeloid leukemia cases.
Genes, chromosomes & cancer - 1 Apr 2003
Albano Francesco, Specchia Giorgina, Anelli Luisa, Zagaria Antonella, Storlazzi Clelia Tiziana, Buquicchio Caterina, Roberti Maria Grazia, Liso Vincenzo, Rocchi Mariano
Abstract excerpt
The Philadelphia (Ph) chromosome is the cytogenetic hallmark of chronic myeloid leukemia (CML) and is observed in more than 90% of CML cases. At diagnosis, in 5-10% of CML patients the Ph chromosome is derived from variant translocations other than the standard t(9;22). Deletions adjacent to the translocation junction on the derivative chromosome 9 were recently described by different groups. The deletions may...
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