Article
Autoantibodies and human leucocyte antigen class II in first-degree family members of Mexican-American type 1 diabetic patients.
The Journal of clinical endocrinology and metabolism - 1 Oct 2001
Zeidler A, Raffel L J, Costin G, Shaw S J, Buchanan T A, Noble J, Rotter J I, Palmer J, Krischer J P, Wait C, Maclaren N K
Abstract excerpt
As part of a genetic study of type 1 diabetes in Mexican-Americans, 360 first-degree relatives of 108 type 1 diabetic probands were studied. Islet cell antibody (ICA), insulin autoantibody, glutamic acid decarboxylase (GAD(65)), and protein tyrosine phosphatase autoantibodies were measured and human leucocyte antigen (HLA) class II alleles DRB1 and DQB1 genotyping was performed. ICA was positive in 37% of the...
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