Article
Young age and HLA markers enhance the risk of progression to type 1 diabetes in antibody-positive siblings of diabetic children.
Journal of autoimmunity - 1 Dec 1998
Yamamoto A M, Deschamps I, Garchon H J, Roussely H, Moreau N, Beaurain G, Robert J J, Bach J F
Abstract excerpt
The contribution of autoantibodies, HLA markers and age to long-term estimates of risk of type 1 diabetes were examined after a median of 11 years (range 7.5-14) during the follow-up in a cohort of 234 siblings (aged 2-29 years) of French children with recent-onset type 1 diabetes, of whom 12 (5.1%) developed diabetes. We evaluated islet cell antibodies (ICA) by indirect immunofluorescence and autoantibodies to...
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